Abstract

Pharmacogenomics is the application of genomic technologies to drug discovery and development, as well as for the elucidation of the mechanisms of drug action on cells and organisms. DNA microarrays measure genome-wide gene expression patterns and are an important tool for pharmacogenomics applications, such as the identification of molecular targets for drugs, toxicological studies and molecular diagnostics. DNA based classification is difficult because the sequence of DNA differs from among all individuals. Genome-wide investigations generate vast amounts of data and there is a need for soft computational methods such as artificial intelligence and expert systems to manage and analyze this information. This study presents a Naive Bayes classifier to a novel approach on application of pharmacogenetics to personalized cancer treatment using data of TPMT polymorphisms.